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DAVID analyses of differentially expressed genes identified molecular function and biological process-related genes through Gene Ontology.
REVIGO highlighted the related functions m RNA and DNA binding, GTP binding, transcription (co)-repressor activity, lipoprotein receptor binding, synapse organization, intracellular transport, mitotic cell cycle and cell death. Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells. doi: 10.1002/glia.20836 Pub Med Abstract | Cross Ref Full Text | Google Scholar Kihira, T., Suzuki, A., Kubo, T., Miwa, H., and Kondo, T. Expression of insulin-like growth factor-II and leukemia inhibitory factor antibody immunostaining on the ionized calcium-binding adaptor molecule 1-positive microglias in the spinal cord of amyotrophic lateral sclerosis patients. doi: 10.1111/j.1440-1789.2007.00776.x Pub Med Abstract | Cross Ref Full Text | Google Scholar Kim, E.
In conclusion, i PSC-derived motor neurons from motor nerve fibroblasts of sporadic ALS patients may recapitulate key mechanisms of neurodegeneration and may offer an opportunity for translational investigation of sporadic ALS.
Large gene profiling of differentiated motor neurons from sporadic ALS patients highlights mitochondrial participation in the establishment of autonomous mechanisms associated with sporadic ALS. doi: 10.1093/nar/gkj102 Pub Med Abstract | Cross Ref Full Text | Google Scholar Kawamoto, Y., Ito, H., Kobayashi, Y., Suzuki, Y., Akiguchi, I., Fujimura, H., et al. Htr A2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and Cu/Zn superoxide dismutase (SOD1) mutant amyotrophic lateral sclerosis.
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