The body's immune system responds by producing antibodies that target the virus.Most individuals who are infected do not develop an active illness, but a rare few will develop a condition related to a disorder of the T-cells.Anti- HTLV-1 Ig M was highest among the subjects in the age group 18-24, 13(39.4%), male 13(20.6%), single 14 (31.4%) and student 14 (37.8%) while Anti- HTLV-1 Ig G was highest among the subjects in the age group 18-24, 15 (45.5%), female 12(19.1%), single 14 (27.5%) and student 14 (37.8%).These results provide more and further evidence that Human T-Lymphotropic Virus 1 is present among blood donors in Ogbomoso and is also one of the transfusion transmissible viral infections Blood donors; HTLV-1; Ig M; Ig G; Seroprevalence; ELISA; Ogbomoso Human T-cell Lymphotropic Virus (HTLV) is also called Adult Tcell Lymphoma Virus (ATCL) or Adult T-Cell Leukemia Lymphoma (ATCLL).Human T-cell lymphotropic virus (HTLV) was the first human retrovirus discovered.HTLV belongs to the Retroviridae family in the genus Deltaretrovirus.
This virus was the first retrovirus to be discovered and identified in 1980 by Poiez, et al. There are two types of HTLV, designated HTLV I and II both of which are transmitted via several routes including sexual transmission, vertical transmission, breastfeeding, contaminated blood transfusion, sharing of sharp objects like needle and syringes or transplantation of infected organs and tissues e.g. The prevalence of contamination of the blood with HTLV-1 has also been reported to be 0.3% in United States of America and 0.7% in Brazil by Abbaszadegan, et al. HTLV-1 transmission by transfusion of cellular blood components has also been reported, requiring testing of blood products in blood banks in high prevalence regions.Phylogenetic analysis of all gene regions confirms this relationship and shows that HTLV-3 falls within the diversity of STLV-3, suggesting a primate origin.However, HTLV-3(2026ND) is unique, sharing only 87% to 92% sequence identity with STLV-3.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Visit for more related articles at Translational Medicine This study was designed to determine the seroprevalence of Human T- Lymphotropic Virus 1(HTLV-1) among blood donors in Ogbomoso, Oyo State, Nigeria Three hundred (300) consenting potential blood donors were recruited into the study over a period of three months (May to July, 2013).Each subject was screened for HIV, HBs Ag and HCV and a structured questionnaire was administered.