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From Center City Philadelphia: Take I-95 to PA 476 North. Take Route 1 South (also called Media Bypass) toward Lima. From City Line Avenue: Take City Line Avenue, US 1 South (approximately 15 miles) until it becomes Media Bypass, just after you cross under Route 320. After crossing Route 452, you will see the Granite Run Mall on your left, Riddle Hospital will be on your right. Take Route 1 South (also called Media Bypass) toward Lima. From New Jersey: Take the Commodore Barry Bridge and follow signs for Philadelphia I-95. After Bypass flows onto Baltimore Pike, follow for approximately 1 mile and turn left at the light by Mc Donald’s. Mention Rothman Institute at Riddle Hospital when making a reservation.