The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD."In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.Bender, Ph D, of National Jewish Medical and Research Center in Denver."The first-generation antihistamines are more sedating, but the distinction isn't as black-and-white as the marketing of the newer products may lead you to believe.
Many sedating antihistamines do not require a doctor's prescription.
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" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.
So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.